There are a number of Speed Keys and shortcuts to help you do things quickly in League Manager:
To quickly find a player, start typing their last name while viewing a view that included player names.
F1 - Brings up Help System
F2 - Recalculate handicaps and point totals is
F7 - Inactivate an active player or Activate an inactive player
F8 - To mark a player in skins, highlight the player and press F8
F10 - Immediately calculates the card. Cards are automatically calculated when you type the last score or exit the card, so pressing F10 is not necessary.
+ - Brings up the scorecard; closes the open scorecard.
TAB - Moves the cursor to the next box in a form
CTRL+E - Exit League Manager